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While this formula has an established history of use overseas, its safety and efficacy have not been fully verified within Japan

If symptoms are intolerable, the prior dose should be reinstated and the taper slowed further

Nevertheless, substantial research efforts are still warranted to bridge the gap between these promising experimental findings and clinical applications, particularly concerning bioavailability optimization and therapeutic regimen standardization ( 4.2 Parkinsons disease (PD) PD is a progressive neurodegenerative disorder pathologically characterized by selective degeneration of dopaminergic neurons in the substantia nigra pars compacta and the presence of intraneuronal proteinaceous inclusions known as Lewy bodies, predominantly composed of -synuclein aggregates (Zhu et al., 2022

PMCID: PMC3646144

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